Thymus is the key organ for development and maturation of T lymphocytes. The dysfunction of thymus leads to decreased immunity or autoimmune diseases. T cells can be divided intoαβ T cells and γδ T ...

The thymus is a specialised primary lymphoid organ that underpins the development and education of T cells. Here, immature progenitors undergo a tightly regulated series of events that not only ...

Researchers have engineered a synthetic Notch receptor system to directly label and profile cells interacting with developing T cells in the thymus. The study identified a broad network of immune and ...

A team of researchers led by Professor Yoko Hamazaki and Assistant Professor Yann Pretemer (Department of Life Science Frontiers) has developed an in vitro model that faithfully recapitulates human ...

French researchers have used a protein called receptor activator of NF-κB ligand (RANKL) to revive the structure and function of the thymus in old mice. The thymus sits in front of the heart and is ...

The thymus is essential for producing the T cells that protect us from infections and cancer. But this organ is also highly sensitive to damage. Treatments like chemotherapy, radiation, and ...

As people age, their immune system function declines. T cell populations become smaller and can’t react to pathogens as quickly, making individuals more susceptible to a variety of infections. To try ...